Overall, the study found that the leading causes of mortality in 2017 were ischemic heart disease, stroke, and chronic obstructive pulmonary disease, while the leading causes of DALYs were ischemic heart disease, low back pain, and major depressive disorder. The study also identified significant differences in the burden of disease across different countries and regions, with lower-income countries experiencing a higher burden of communicable, maternal, neonatal, and nutritional diseases, while higher-income countries had a higher burden of non-communicable diseases.

This study has important implications for public health practice and policy, as it highlights the need for targeted interventions and resources to address the leading causes of mortality and DALYs in different countries and regions. For example, lower-income countries may benefit from increased funding for communicable disease prevention and treatment, while higher-income countries may need to focus on reducing the prevalence of risk factors for non-communicable diseases, such as tobacco use and poor diet.

In conclusion, the Global Burden of Disease Study 2017 provides valuable insights into the global burden of disease and injury and its distribution across different countries and regions. Its comprehensive and rigorous approach to data collection and analysis strengthens its potential contribution to public health practice and policy, by identifying areas where interventions and resources are most needed to improve health outcomes worldwide.