Describe the SACT regimen in detail, what drugs are involved, how do these drugs work towards killing cancer, drawing on the underpinning literature.

The essay needs to incorporate the following:● Introduction:-You need to include a strong introduction that outlines your topic (aspect of systemic anti-cancer therapy), and the reflective model you chose and why.● of the situation and identify the aspect to explore:-Describe the situation you are trying to make sense of (a situation in practice, or something that you have read that seems important, but that at the moment you are trying to understand).-What was good and not so good about the situation/issue from your reading? Use this to identify the aspects to explore, i.e., what aspect of systemic anti-cancer therapy administration from the situation/issue are you going to explore.Make sure you focus only on one aspect with your essay, and you don’t try to explore everything.● Main body/analysis:-Describe the SACT regimen in detail, what drugs are involved, how do these drugs work towards killing cancer, drawing on the underpinning literature.-Analyse, with reference to the underpinning evidence base, the aspect of systemic anti-cancer therapy administration you have chosen to explore (for example the efficacy; side-effect(s) etc). Discuss the evidence base and analyse the theory in-depth (for example, clinical guidelines, local and national policy, primary research, and other evidence). Critically apply knowledge of cancer biology to support your discussion.-Reflect on the autonomous and/or holistic management to ensure safe administration of SACT.-Consider relevant guidelines /frameworks and apply theoretical and research evidence to support your discussion.-Demonstrate your critical thinking by dissecting the evidence you have explored. Be sure to explain / clarify the judgements you make about the statements you give and how these apply in clinical practice.● Synthesis and action plan:-What sense can you make of the situation/issue now, are there alternative approaches; evaluate what you have learned.-Consider how you will utilise what you have learned, and in partnership with the patient, family, and the multidisciplinary team, how it will enhance and develop your own knowledge and skills to assess and manage a patient experiencing systemic or intravesical anti-cancer therapy in the future.● Conclusions:-Summarise what your essay has covered.
Answer & Explanation
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The SACT (Systemic Anti-Cancer Therapy) regimen is a treatment protocol used to kill cancer cells in the body. This treatment involves the use of various chemotherapy drugs that are designed to attack and destroy cancer cells. The drugs used in SACT are selected based on the type of cancer being treated and the patient’s overall health.

Chemotherapy drugs used in SACT are typically categorized based on their mechanism of action. Some drugs directly attack cancer cells by interfering with their ability to divide and grow, while others target the blood vessels that supply the cancer cells with nutrients, oxygen, and other necessary materials.

One common SACT regimen is the combination of cyclophosphamide, doxorubicin, and vincristine (CAV), also known as the CHOP regimen. This regimen is used to treat non-Hodgkin’s lymphoma and other types of ca

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Step-by-step explanation
ncer. Cyclophosphamide is a cytotoxic drug that works by damaging the DNA of cancer cells, preventing them from dividing and growing. Doxorubicin is a drug that inhibits the DNA replication process by intercalating into the DNA helix, forming free radicals that damage cancer cells. Vincristine works by disrupting the cell division process and preventing cancer cells from dividing.

Another commonly used SACT regimen is FOLFOX, which is used to treat colorectal cancer. This regimen includes the drugs oxaliplatin, leucovorin, and 5-fluorouracil (5-FU). Oxaliplatin is a platinum-based chemotherapy drug that works by binding to DNA and inhibiting cell division. Leucovorin is a form of folic acid that enhances the effectiveness of 5-FU, which is a chemotherapy drug that inhibits cell division and replication.

In addition to these drugs, other drugs such as bevacizumab and cetuximab may be added to the SACT regimen to target the blood vessels that supply cancer cells with nutrients, oxygen, and other necessary materials. These drugs are known as targeted therapies and work by inhibiting the formation of new blood vessels in tumors, which can slow or stop the growth of cancer cells.

While SACT can be an effective treatment for cancer, it can also cause side effects, including nausea, vomiting, hair loss, and fatigue. However, advances in cancer research and drug development have led to the development of newer chemotherapy drugs that are less toxic and have fewer side effects.

Overall, SACT is an important component of cancer treatment, and its success is based on the selection of the most appropriate drugs for the specific cancer being treated, as well as the overall health of the patient.

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